Genome-scale Integrated Analysis of gene Networks in Tissues. Relevant tissues for query genes. GIANT leverages a tissue-specific gold standard to automatically up-weight datasets relevant to a tissue from a large data compendium of diverse tissues and cell-types. The resulting functional networks accurately capture tissue-specific functional interactions. Troyanskaya Laboratory - Princeton University.

This server performs in silico nano-dissection, an approach we developed to identify genes with novel cell-lineage specific expression. This method leverages high-throughput functional genomics data from tissue homogenates to accurately predict genes enriched in specific cell types. Defining cell type specificity at the transcriptional level in human disease.

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This collection of tools is a subset of the tools, applications, and libraries developed within the Center for Quantitative Biology. They are provided here within a common framework, called the CQB Integrated Tools. Which allows for data to be processed and passed between them easily. The Integrated Tools framework also supports batch processing for multiple data sets natively within each tool and utilizes the local computing grid for high throughput.

What is a query? A query is a gene or a gene-set representing a biological theme that a user wants to investigate. Examples of a good query include genes from a common transcriptionally regulated pathway or process, a cellular component, a molecular complex, or a differentially expressed gene list or biomarker list. Start by entering a query, like GLI1 GLI2 PTCH1.